Tuesday, February 17, 2026

Chat GPT Searches the Web for "Dry Lab" Bioinformatics

 Please research Pubmed for papers that use the specific term "dry lab" to refer to bioinformatics in genomics. Eg "wet lab" is an ILMN sequencer and "dry lab" is sending the BAM files somewhere for diagnostic bioinformatics. I have seen "dry lab" used in AMA PLA documents and in CAP documents re CLIAC committee on NGS. But I'm not sure how standard it is. At pubmed, please return up to 5 publications (with PMID) that use Dry Lab in the context of bioinformatics. Please return up to several citations from OTHER sources on the internet other than Pubmed. tagdrylab

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Here’s what I found from PubMed and other sources regarding the specific usage of the term “dry lab” in the context of bioinformatics/genomics data analysis (as opposed to generic distinctions like education or computational biology broadly). Only a few PubMed-indexed articles actually use the phrase “dry-lab” or “dry lab” explicitly in the abstract or workflow context.

✅ PubMed Publications (PMIDs) Using “dry lab” in a Bioinformatics / Genomics Context

  1. Yu et al., 2023 — Multi-layer dry-lab and wet-lab methodology in genomics analysis
    Transcriptomics data mining to uncover signature genes in …
    PMID: 38058845

    • Uses the phrase “multi-layer dry-lab and wet-lab methodologies” to describe integration of computational analysis (bioinformatics) with wet lab data for biomarker discovery.

  2. Payton et al., 2023 — Dry lab vs wet lab in toxicology (computational focus)
    Navigating the bridge between wet and dry lab toxicology research…
    PMID: 37304253

    • Discusses “dry lab” researchers in computational analysis of high-dimensional data vs wet lab experimentalists.

  3. Lepuschitz et al., 2020 — WGS analysis pipeline definition
    Analytical Performance Validation of Next-Generation …
    PMID: 32849463

    • Describes wet-lab and dry-lab workflows in whole-genome sequencing and bioinformatics pipelines, explicitly discussing “dry-lab analysis of WGS data.”

  4. Griffiths et al., 2024 — PHA4GE QC tags for genomics
    PHA4GE quality control contextual data tags
    PMID: 38860884

    • Uses “wet- and dry-lab procedures” in the context of genomic sequencing and bioinformatics workflows in public health labs.

  5. Xiaoli et al., 2022 — SARS-CoV-2 surveillance “Dry Lab Group”
    Benchmark datasets for SARS-CoV-2 surveillance bioinformatics
    PMID: 36093336

    • Refers to a “Dry Lab Group Laboratory and Testing Task Force” in SARS-CoV-2 genomic bioinformatics.

🔎 Context from Non-PubMed Sources (Web/PMC, Internet)

These do not have PMIDs [BQ yes they do] but are relevant to defining and understanding how “dry lab” is used in genomics / NGS bioinformatics:

  • Spatola et al., 2024 (PMC): Explicitly contrasts wet-lab and the “dry-lab phase” as referring to NGS data-processing and bioinformatic analysis.  PMID: 38998608

  • Robinson et al., 2024 (PMC): Uses the term “dry lab researchers” to describe computational biologists.  PMID: 38900718

  • Many educational and policy articles define “dry lab” as computational work (e.g., bioinformatics, in-silico) vs hands-on wet lab activities.  PMID: 29167223

📌 General Observations about Terminology Use

✅ Term usage is real but not ubiquitous:

  • “Dry lab” does appear in published abstracts when authors explicitly discuss workflow phases in sequencing or analysis pipelines.

  • However, it is still not widely standardized as a formal MeSH term or tightly defined technical term in genomics literature.

⚠️ Terminology varies by field/community:

  • Some articles use “dry-lab phase” to describe the data analysis stage of NGS workflows.

  • Others use it as a broad label for computational scientists (dry lab researchers).

  • In genomics clinical guidelines (e.g., CLA/AMA/CAP), the implicit usage matches what you describe (sequencer = wet lab, bioinformatics = dry lab), but this is more common in practice documents than research PubMed abstracts.

🧠 Examples of How “Dry Lab” Is Used in Abstracts You Can Cite

Example phrases from PubMed articles:

  • “…multi-layer dry-lab and wet-lab methodologies were adopted…” (HNSC transcriptomics study).

  • “challenges for … computationally focused, ‘dry lab’ researchers…” (toxicology data).

  • “…wet-lab and dry-lab workflows were developed…” (WGS bioinformatics).

  • “…wet- and dry-lab procedures…” (public health genomics QC).

  • “…SARS-CoV-2 Emerging Variant Sequencing Project Dry Lab Group…” (bioinformatics task force).

🧾 Summary of Key Publications (with PMIDs)

  1. Transcriptomics data mining… — PMID: 38058845

  2. Navigating the bridge…dry lab toxicology — PMID: 37304253

  3. Analytical Performance…wet-lab and dry-lab workflows — PMID: 32849463

  4. PHA4GE quality control…wet and dry lab — PMID: 38860884

  5. Benchmark datasets…Dry Lab Group — PMID: 36093336

📍 Concluding Notes

  • “Dry lab” does appear in the PubMed literature in the specific sense of computational/bioinformatic analysis, though not always consistently and often in descriptive workflow contexts rather than as a controlled term.

  • Use in clinical genomics guidance (e.g., CAP/CLIA/CLIAC) reflects a similar distinction but may not always show up in research PubMed abstracts.

  • The term remains somewhat informal and context-dependent rather than an established indexing term in genomics publications.

If you want, I can compile the PubMed abstracts and direct quotes in full or search specifically within CAP/CLIAC/AMA documents to see formal usage in guideline language as well.

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From CLIAC document (BQ) no longer online





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