Wednesday, July 3, 2024

AI Corner: Fun Fact: Run an Auto Transcript through an AI Fixer

 Otter.ai and other subscriptions services provide high quality "automatic transcripts" from audio files.   For example, I recently fed a five-hour government CMS web meeting through this service.

With ordinary conversations, Auto Transcript is pretty spot-on.   However, with detailed  technical material, it's more likely to make mistakes.

Here's a workaround.   Make the auto transcript of the public meeting (or youtube meeting) via a service like Otter.AI.   It will do the best it can, but it will never add or subtract words from what it attempts to transcribe.

THEN, as step two, feed the Auto Transcript into CHAT GPT (or another AI) and ask it to "fix" the Auto Transcript.   The result will be better, because the Chat GPT AI will feel able to make small changes for sense or common sense, and will probably improve sentence flow and paragraphing or headings.

Here's an example from a June 25, 2024, web-streamed CMS lab meeting on new test pricing policy.  Note, I've manually inserted test names that were unavailable in the audio file.

###

PROMPT: 

This is an Auto Transcript, which naturally has some errors or awkward grammar. 

 Please improve it, but make only minor changes for clarity and stay very close to the auto transcript.

[AUTO TRANSCRIPT otter.ai]

Speaker 6  40:23 

Thank you. My name is Michelle Aldrich and I am the clinical lab laboratory director for Europeans transplant genomics. I'm here today to talk about the newly approved category one CPT code 815 6x for true graph kidney. Next slide please. This test is a gene expression profile to be used after kidney transplantation as a way to detect a subclinical rejection with the goal of improving long term outcomes of kidney transplantation and reducing the need to either go back on dialysis or have a second transplant the methodology is listed there. And the other alternative for this test is it will avoid the need for invasive and costly surveillance biopsies. Next slide. And so this slide lists the resources necessary to perform the test both from a reagent consumable equipment and a labor standpoint, as illustrated these resources are substantial. In addition, of course, there was heavy r&d involved in the development in many clinical studies that have been performed. To demonstrate the clinical validity and clinical utility of this assay. It is currently approved by modex under General LCD. Next slide please. So our crosswalk recommendation is to crosswalk to CPT code 81595, which is a similar test it is a gene expression profile in the cardiology transplant space. It utilizes 20 genes 11, which are specific for the test nine which are housekeeping and it does report a rejection risk. Next slide please. If we wanted to compare the test a little closer, you can see that there are a couple of differences. Initially, I'm from a sample type perspective, the heart transplant test 81595 does utilize whole blood that has been undergone a purification step to look at only PBMCs and then extracts RNA from those cells. In contrast, 815 6x or our new kidney CPT code does extract RNA from whole blood that has been collected in an RNA specific PAXgene to the other main difference is the heart transplant looks only at 20 genes while we were looking at 139 genes, both of them then go through a bio informatics algorithm with similar types of reporting regarding the status of rejection, and of the allograft. And that's all I have, are there any questions?

 

AI IMPROVED VERSION

Chat GPT:

#

AGENDA 26

TRANSPLANT GENOMICS

Thank you. My name is Michelle Aldrich, and I am the clinical laboratory director for [Eurofins] Transplant Genomics. I'm here today to talk about the newly approved Category One CPT code 8156X for TruGraf Kidney.

  • ·        Transplantation medicine (allograft rejection, kidney), mRNA, gene expression profiling by quantitative polymerase chain reaction (qPCR) of 139 genes, utilizing whole blood, algorithm reported as a binary categorization as transplant excellence, which indicates immune quiescence, or not transplant excellence, indicating subclinical rejection

 

Next slide, please.

This test is a gene expression profile used after kidney transplantation to detect subclinical rejection, with the goal of improving long-term outcomes and reducing the need to either return to dialysis or undergo a second transplant. The methodology is listed here. An alternative benefit of this test is that it will avoid the need for invasive and costly surveillance biopsies.

Next slide.

This slide lists the resources necessary to perform the test from a reagent, consumable, equipment, and labor standpoint. As illustrated, these resources are substantial. Additionally, there was significant R&D involved in the development and many clinical studies performed to demonstrate the clinical validity and utility of this assay. It is currently approved by MoDEX under General LCD.

Next slide, please.

Our crosswalk recommendation is to crosswalk to CPT code 81595, which is a similar test. It is a gene expression profile in the cardiology transplant space, utilizing 20 genes—11 specific for the test and 9 housekeeping genes—and it reports a rejection risk.

81595, $3240 (Allomap, CareDx)  Cardiology (heart transplant), mrna, gene expression profiling by real-time quantitative pcr of 20 genes (11 content and 9 housekeeping), utilizing subfraction of peripheral blood, algorithm reported as a rejection risk score

Next slide, please.

If we compare the tests more closely, there are a few differences. From a sample type perspective, the heart transplant test 81595 utilizes whole blood that has undergone a purification step to isolate PBMCs and then extracts RNA from those cells. In contrast, 8156X, our new kidney CPT code, extracts RNA from whole blood collected in an RNA-specific PAXgene tube. Another key difference is that the heart transplant test looks at 20 genes, while our test looks at 139 genes. Both tests then go through a bioinformatics algorithm with similar types of reporting regarding the status of rejection and the allograft.

That's all I have. Are there any questions?